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Definitely one of the hardest matchups for Senna by far. His engage and lock down is just a straight up counter to a poor innocent immobile baby like Senna, pretty much a perma ban for me.
Pyke
Same with blitz basically, if he roams there's really nothing you can do about it. Keep vision and make sure you know where he is, if its a bad Pyke you're fine though.
Nami
Honestly one of the most annoying enchanters this season, she abuses the heck out of imperial mandate and its hell to play against her in lane. Her sustain is higher and her crowd control is higher, make sure to rush executioners calling.
Leona
If you just stay out of range of her E you should be fine in lane. Once she hits 6 though be super cautious because even the slow from the outer ring can screw you over.
Samira
Your auto attacks can go through her W and you're longer range then her. Samira is very reliant on her support so if her support sucks she'll suck.
Janna
No need to get executioners unless shes building Moonstone renewer. Dodge her tornados and try to trade a lot levels 1 and 2. If you get hit with her W just back up and try your best to not get caught.
Alistar
Considering barely anyone plays him and the people who do play him are either really bad or really good, he still counters Senna pretty hard. Try not to get to close to him and just poke from afar with your Q. Be careful when he hits level 3 because his all in potential is gross in the right hands.
Zyra
Like with most champs you go against, if you don't wanna die, don't get caught. She can only really burst you down if she roots you, and her plants that are triggered from her E slow you so keep that in mind when going to trade because even if she misses the root she can still slow.
Morgana
Not a very tough matchup depending on what she builds. If she builds enchanter it should be easier, if she builds full ap it'll be a little more tough because of the extra dmg she'll be doing. Just play around the minions to stay away from her 500 second root.
Ashe
With Ashe you wont even need glacial because Ashe has one built into her kit. If she lands her R on someone try to follow up with your W.
Morgana
If you're playing ADC Senna this works surprisingly well. When morgana hits a Q try and follow up with a W.
Jhin
I think this is one of the most popular ADC's to go with Senna support but I really don't think its that amazing and there are definitely better options. This is one of those matchups that it just depends on the skill of the player, if you hit a Q or land a W you better hope Jhin follows up with a W.
Lucian
For obvious reason they go great together, this works especially well if you're against a more squishy bot lane that can be abused more. If you play with a Lucian just make sure to poke poke poke, you both should be going in at around the same time.
Synergies
IdealStrongOkLowNone
Ashe
With Ashe you wont even need glacial because Ashe has one built into her kit. If she lands her R on someone try to follow up with your W.
Morgana
If you're playing ADC Senna this works surprisingly well. When morgana hits a Q try and follow up with a W.
Jhin
I think this is one of the most popular ADC's to go with Senna support but I really don't think its that amazing and there are definitely better options. This is one of those matchups that it just depends on the skill of the player, if you hit a Q or land a W you better hope Jhin follows up with a W.
Lucian
For obvious reason they go great together, this works especially well if you're against a more squishy bot lane that can be abused more. If you play with a Lucian just make sure to poke poke poke, you both should be going in at around the same time.
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