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When she uses her R on you, you can not use abilities...
Draven
Much damage, be careful, but you can poke him easily throwing your bombs in his axes.
Blitzcrank
Don't be grabbed.
Morgana
Her Q, E is a sucks.
Leona
Be careful.
Jinx
Her R can surprise you, pay attention on it.
Ezreal
Hir R can surprise you, pay attention on it.
Vayne
I really like to play with Vayne adc, you can use your E to buff and slow, to her has kiting better, your R can save she, and Vayne is an adc that have much escape, and you can buff and deal much CC to her, just stay alive until level 6.
Yasuo
Don't need to raise a champion to have a synergy with Yasuo, Yasuo is a champion that have much mobility, and the Zilean's kit is full CC, Yasuo can stack his tornado to rise them so easy, because Zilean has a so cancer CC, I recommend you to not pick ZIlean if there is a Yasuo that you not know, because Yasuo is a champion so hard to play, and he will not know the better time to be agressive and he will be much poked in the lane, okay? trust on me, a well played Yasuo and a Zilean do a powerful combination.
Draven
A well played Draven will enjoy your abilities.
Jhin
Jhin is an adc that needs much CC to deal damage, because his damage scales better when the enemy have a bit of life, poking and buffing Jhin with your E and dealing CC on the enemy, will be so hard to hit Jhin.
Kalista
She can stack so easy her spears and be saved by Zilean.
Heimerdinger
ZIlean's kit and Heimerdinger will be the hell in bot lane, the unique weakness of Heimerdinger is not has escape, but Zilean has E and R, if he dies, you can use your R and Heimerdinger's turrets will deal much damage.
Ashe
Lucian
Miss Fortune
Kai'Sa
Caitlyn
Caitlyn is an adc that CC is much good, but if she stay bad positioned, she can die easily from another CC champion, like Nautilus, Blitzcrank, Morgana, maybe you have your R, but these champions has much CC, Caitlyn can not run away from them, Zilean and Caitlyn is ok, but have better choices.
Tristana
Aphelios
Synergies
IdealStrongOkLowNone
Vayne
I really like to play with Vayne adc, you can use your E to buff and slow, to her has kiting better, your R can save she, and Vayne is an adc that have much escape, and you can buff and deal much CC to her, just stay alive until level 6.
Yasuo
Don't need to raise a champion to have a synergy with Yasuo, Yasuo is a champion that have much mobility, and the Zilean's kit is full CC, Yasuo can stack his tornado to rise them so easy, because Zilean has a so cancer CC, I recommend you to not pick ZIlean if there is a Yasuo that you not know, because Yasuo is a champion so hard to play, and he will not know the better time to be agressive and he will be much poked in the lane, okay? trust on me, a well played Yasuo and a Zilean do a powerful combination.
Draven
A well played Draven will enjoy your abilities.
Jhin
Jhin is an adc that needs much CC to deal damage, because his damage scales better when the enemy have a bit of life, poking and buffing Jhin with your E and dealing CC on the enemy, will be so hard to hit Jhin.
Kalista
She can stack so easy her spears and be saved by Zilean.
Heimerdinger
ZIlean's kit and Heimerdinger will be the hell in bot lane, the unique weakness of Heimerdinger is not has escape, but Zilean has E and R, if he dies, you can use your R and Heimerdinger's turrets will deal much damage.
Ashe
Lucian
Miss Fortune
Kai'Sa
Caitlyn
Caitlyn is an adc that CC is much good, but if she stay bad positioned, she can die easily from another CC champion, like Nautilus, Blitzcrank, Morgana, maybe you have your R, but these champions has much CC, Caitlyn can not run away from them, Zilean and Caitlyn is ok, but have better choices.
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