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First of all my excuses for the late answer since I was on holidays, I will update my Runes section and make sure that I'll explain all the Runes on LeBlanc, for now It's most important to know that Inspiration could indeed be good on LeBlanc if you are a player that is struggling to find succes in lane. It also helps to get the extra regen and movespeed when you use your potions since you always start corrupting pot on her, I like to play for Sorcery because it gives me more late game options with the Mana or Cdr plus the extra damage from scorch. So Inspiration is for generally the early game and pressure, whilst Sorcery gives you more late game options and damage.
Hope this answer could help for now!