It's time for the 2025 Season 1 Guide Contest! Create or update guides during the following 6 weeks to compete for the $3,750 prize pool. 🏆
LoL Best Vayne ADC Build Guides 2025
Build guides for Vayne ADC on MOBAFire. Find recommended items and runes by high ranked players to learn the best Vayne ADC builds. Create your own champion guide!
Season 7 Builds
![]()
VAYNE IS MY MAIN
VAYNE IS MY MAIN
![]()
Vayne | The three-shotting legend
Season 6 Guides
![]()
Vayne Late Game Hyper Carry
![]()
Pew Pew Pachoom! 3 shotting your way to victory with Vayne!
![]()
Legendary Mechanics (FRESH - Tutorial Video + New Montage)
![]()
Vayne's Tears Of Malevolence S6.18 (Unique Guide) Two Builds
![]()
The Ultimate Vayne Guide
![]()
All aspects of Vayne
![]()
[S6] - Free Elo waves with Vayne (Deep guide)
![]()
Not so Useless Vayne Guide + matchups + funny things
![]()
SEASON 6 VAYNE: Enter The Vanity Cannon
![]()
New Overpowered Vayne Build
![]()
Vayne A caçadora de Br´s
![]()
Beta Vayne 6.10
![]()
THE Vayne Freelo Guide - In Depth Patch 6.8
![]()
Purging with Silver: A 6.8 Guide to AD Carry Vayne
![]()
For little knows my royal dame that Shauna Vayne is my name!
![]()
Maximizing Vayne's Potential - 6.2(updated every patch)
![]()
Vayne, Dawn Of The Night Hunter [5.24] [Pre-S6]
![]()
The die is cast
Create Your Champion Build Guide
Share your strategy for your favorite champion with the largest League of Legends community!
CreateYour Guide!
