This is mainly because my build gives vayne a much easier time in the laning phase And since vayne is squishy my masteries and runes help to give vayne at least 565 hp and 72 ad with the Dagger and 0.76 attack speed at level 1. And since vayne has no sustain early on, you have 4 Health Potions to last the laning phase giving you a super advantage over your opponent adc. I am not a good adc but i know that my build works, if used by a good adc, this build will show its full potential.
Cheers to all you vayne adcs out there.

-Cons
-High skill-capped
-One wrong tumble might kill you!
- Condemn may save your opponent if used wrongly

-Pros
-This build gives you a strong laning phase
-Enough attack speed to kite your opponent really well
-Probably the strongest sustain in lane as an adc
-Easy last-hitting creeps
-Shreds anyone mid/late game due to Fervor of Battle
-Difficult to shut down
-Almost never loses trades with most adcs

This masteries and runes that i personally designed myself specifically for vayne, gives vayne 26 armour , 565 hp , 72 ad , 0.76 attack speed and 41 magic resist at level 1 with 4 Health Potions

The standard vayne runes/masteries gives vayne 28 armour , 577hp ,73 ad ,0.77 attack speed and 43 magic resist at level 1 with only one hp pot ....but 5% life steal which is only a big thing when its mid-late game.(Lets be honest here ,pots beat 5% life steal early on )

- Greater Seal of Health 2 flat hp yellows for 18 hp , this is to help with Vayne's low hp early on. But i use two because Veteran Scars gives me 50 hp already.And i need some armor too.

- Greater Seal of Armor As an Adc fighting another Adc,YOU NEED IT PERIOD.

- Greater Glyph of Magic Resist you will definitely need this against an AP heavy support or against an ap jungler

- Greater Glyph of Attack Damage To make up for the AD.

- Greater Mark of Attack Damage To make up for the AD.

- Greater Quintessence of Attack Damage POWER OVERLOAD ,jk to make up for the AD.

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Ferocity Tree:18/0/0

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- Fury Attack speed is one of the core stats as an adc compared to Ability Damage, Sorcery

- Feast Restores 20 hp on a last hit but 30 seconds cooldown. In 10 mins, 400 hp would be restored. Double Edged Sword my vayne build may give you a ton of sustain but taking 1.5% additional damage isn't something you should be using in lane as you are normally the one that gets harassed in lane.

- Vampirism Putting four points into this mastery gets me 2% life steal and spell vamp.Because the system rounds up numbers. 1.6% --> 2%

- Natural Talent Thus i put one point into Natural Talent for maximum damage sustain trade off. I got an additional AD for putting one point into this talent while still having 2% life steal and spell vamp :3.

- Oppressor Well the reason i didn't take Bounty Hunter because i have condemn and i also have Blade of the Ruined King's active. Therefore, this is better. Yes I'm bronze and i suck so much that i can't guarantee that i be able to use Bounty Hunter .

- Battering Blows You need an explanation? oh yes you play ap vayne.

- Fervor of Battle My first item is Phantom Dancer,Since i don't have an AD item. This goes really well with my build. More attack speed=Faster stacks of fervor.

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Resolve Tree:0/0/12

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- Recovery just extra regen to go with Perseverance .

- Tough Skin Reduced damage of both champion and monster auto-attacks.Your fighting against another adc.Since adc's main damage is from autos.This is precisely why i chose this mastery.

- Veteran's Scars adc's need the hp and this goes really well with my 2 Greater Seal of Health.

- Perseverance 50% increased health regeneration to go with Recovery . When under 20% hp, it goes up from 50% increased health regeneration to 200% increased health regeneration.This is the part that just gives me insane survivability as an adc(21 hp regen per 5 seconds!).You just cannot die with this mastery (unless you get caught out)

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First lets analyse Thunderlord's Decree is very good when it comes to bursting your opponent down in all phases of the game as it scales with bonus ad and it increases according to your level.So it does 253.5 additional damage on your third attack at level 18 including my bonus ad. Due to natural talent i also have some bonus ap to give it more damage.

Now Fervor of Battle is really good because you really need the AD and you need Fury tree. And since you won't be having items that have AD till Infinity Edge, this is much better. As Thunderlord's Decree scales with ad and ap,its inferior. You be surprised how much damage you do with Fervor of Battle due to your attack speed from Phantom Dancer early on.

Fervor of Battle reins supreme in this build.

5%LifeSteal from the Doran's Blade and Vampirism compared to Perseverance and Recovery , firstly if you use the standard vayne runes/masteries you would have 73 ad. If you use my build , you should have 66 ad with my long sword. 5% Lifesteal of 73 ad is 3.65 hp per shot regen.

Now my build , Perseverance and Recovery makes me regen 10 hp per 5 seconds

Practical data, if you were to have 5% life steal and you auto twice per 5 seconds, you would regen 7.3 hp per 5 seconds , Perseverance and Recovery would still easily over heal 5% life steal from Doran's Blade and Vampirism .As i regen 10 hp per 5 seconds. And when I'm below 20% hp, i would regen up to 21 hp per 5 seconds. which is insane for survival!.

If you use the standard vayne runes/masteries and buy Doran's Blade. You would have 577+hp but you would have 1 Health Potion! 28 Armor and 43 Magic resist for this build


If you use my build , you would have 565+ hp and still have 4 Health Potions to back yourself up in the lane even if you were to lose a trade against your lane opponent you can easily stay in the lane way longer than your opponent while still being able to farm safely due to my masteries and runes. 26 Armor and 41 Magic resist for this build.

-I first start of with A dagger and 4 Health Potions and
rush into phantom dancer for the 12% damage reduction for the last person you hit. I still have Fervor of Battle to increase my overall damage as well as my dueling capabilities.

-I then get Boots as the name suggests, for some serious movement speed increase due to Phantom Dancer's passive "increased movement speed by 7%"

-I follow up the build with an Infinity Edge that gives me 70 ad, 20% critical strike chance and the passive which increases your critical strike damage by a whopping 50%! At this point you would have 50% critical strike chance. Which is an insane amount no matter how much you look at it. I know many of you are used to having more than 50% critical strike chance but you also must know that if you played other games before. 50% critical strike chance is an insane amount.(Its more than enough!) But of course your 6th item can be more crit/attackspeed its not wrong. I'm just stating the fact that 50% critical strike chance is a lot in any game you play.

-After that i follow up with a Berserker's Greaves for 35% attack speed and an additional 15 movement speed to kite better.

-I then follow it by getting a Vampiric Scepter then a Recurve Bow instead of getting Bilgewater Cutlass first(get both if you have the money.Remember getting botrk this way is stronger and more efficient! , then finish it off by getting a Blade of the Ruined King. Get ready for the power spike BABY!

-Get Quicksilver Sash before Lord Dominik's Regards unless the enemy has little to no-cc.

-My fifth item is Lord Dominik's Regards due to the hp passive and the bonus armor penetration for late game to fight strong tanks like rammus and malphite.

-You can also replace Lord Dominik's Regards with Mortal Reminder to deal with superb sustain bruisers
and adcs .

-But Lord Dominik's Regards can be replaced by Statikk Shiv for more crit and attack speed with a nice on-hit area of effect passive when your enemies have little to no armor.

-Finish your Quicksilver Sash into Mercurial Scimitar. But if you didn't buy Quicksilver Sash as theres little to no-cc. Buy Bloodthirster.For the 350 shield that it can provide.Really good defence option at the same time giving you 75 AD plus 20% life steal.

-The last is old school,not much to be explained about getting a Guardian Angel except that if you do proc this item , sell it and get one of the above.Overall,i rarely get this item unless i need a ton of defence.(RENGAR!) cough...

Its very important to note that even with my runes/masteries. You still can't go ham at level 1.
At level 2,when you have your Silver Bolts you can trade with almost anyone due to your attack speed.
This build helps adc with farming as most vaynes including me have problems last hitting under tower/pressure.
The Dagger and 4 Health Potions plus my runes/masteries keeps the pressure off as you will have solid sustain/tankiness in lane. And still able to destroy your opponent with your attack speed.

As vayne, it really is key to stay behind your team and close to your support.I really cannot emphasise this enough. As vayne, being caught out means death!
Many including myself have always dreamed of making plays and always forget the importance of positioning and decision making.
When entering team fights, its best if you have both summoner spells up.But thats rarely the case.
Regardless as vayne or any adc out there, you must know when your opponent spells are up, always keep in mind if they have any crucial cc/gap-closers.Predict it and dodge it. If not at least put yourself in a proper position to minimise the damage done to you as much as possible.
And it normally means staying with your SUPPORT!

This is known by many names.
This mechanic is very crucial when playing adcs like vayne!
In order to this perfectly you must fully understand her kit entirely.
I encourage you to watch his videos to kite better with vayne! Play Video
TIP: When "kiting", make sure your mouse is not hovering over enemy units as this might mess you up.

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Her entire kit:

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Vayne's Passive Night Hunter:
Vayne ruthlessly hunts evil-doers. She gains 30 Movement Speed when moving towards an enemy champion.

-Always keep this in mind when you chase opponents.This passive is amplified by three times when you use final hour.

Vayne's Tumble/Q:
Vayne tumbles, maneuvering to carefully place her next shot. She rolls toward the cursor and her next attack deals 30/35/40/45/50% bonus damage.

-This is mainly used as an auto-reset in lane.In team fights , only use this to get out of a sticky situation. And do not use this when your opponent is cced late game as during late-game your attack speed would do more dps than using tumble. I max this skill second as i don't need auto resets that much with my early-game attack speed.

Vayne's Silver Bolts/W
Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target will deal 6 / 7.5 / 9 / 10.5 / 12% of the target's maximum Health as bonus true damage (Max damage vs. monsters is capped at 200).
Silver Bolts' damage bonus cannot fall below 40 / 60 / 80 / 100 / 120.

-Your main damage , I max this skill first as this is your main dps skill. A good way to proc this really fast early game is AA,Tumble AA and condemn. But it chunks a lot out of your mana so i don't recommend it.With my attack speed you should be able to proc this quite rather easily during the laning phase.

Vayne's Condemn/E:
Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, dealing 45/80/115/150/185 (+0.5 per bonus attack damage) physical damage and knocking them back (900 units). If they collide with terrain, they are impaled, dealing 45/80/115/150/185 (+0.5 per bonus attack damage) bonus damage and stunning them for 1.5 seconds.

-Remember to use this when your opponent is near a wall. But this also can be used to trade.When escaping,situations when your opponent is not near a wall do not hesitate to use it as it will save your life! This spell has a really long cooldown so use this very wisely.This ability also applies Vayne's Silver Bolts. So a nice combo would be to auto Tumble and Condemn for the a fast trade to proc your Silver Bolts.

Vayne's Final Hour/R:
Readying herself for an epic confrontation, Vayne gains 30/50/70 increased attack damage, 1 second stealth during Tumble, and triple the bonus movement speed from Night Hunter lasting 8/10/12 seconds.

-Her ultimate can be used with her tumble to stealth up and reposition yourself. Sometimes its better not to attack instantaneously. Remember! use this with tumble to reposition yourself or to dodge incoming skill shots.Even if you feel like using Tumble for more burst thats only against another ADC. Because you definitely need the stealth when fighting champions like .

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You can start Condemn on your opponent and Flash in another position, catching him/her off guard as you can flash to change the trajectory of Condemn's path to stun your opponent.
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Same goes for your Tumble.

When fighting dragon/baron Tumble against the wall for higher dps to take it down faster as there is almost no animation when you Tumble against a wall.

Flash-You made a mistake? You don't wanna die? Take this summoner spell,it helps you get out of almost any dangerous situation.
Heal-Some may ask why not take Barrier?,yes indeed but heal gives a movement speed buff which is really helpful to escape or kite.

Thanks guys for looking up my guide i hope you guys enjoyed it and will become better vayne players! Leave an upvote and comment if you wish to clarify anything regarding this unique build that i have experimented with countless times in games.

Cheers,
GearkingX