You wanna play it semi-safe and let them come to you, worst idea is jumping on them when they have the potential to kill you!

They'll lose patience thinking you're squishy and jump on you, that's when you'll strike.
You'll want to keep heading away from them while you attack if they chase you.

Don't be overly aggressive, the point of all of this is that you always need to be wary of the enemy and your surroundings, you'll scale hard and then it's when you'll punish them.

Always try to scare them away by setting up minions for Q, they'll never stay close and if they do you'll hurt.

Place E in bushes for visual, stop a gank or if you are pushed or around mid lane, ALWAYS one behind you towards the tower, if they jump on you or the jungler shows up, that E is your safety and only hope if you're not fed, if they are close to you, lead them to the E and W instantly to stop them on their tracks, just run away.

E can be used for a little burst on a big wave with a grenade followup and a W if needed to clear up some more.

Use R when they are about 1/4 health, you'll most likely kill them easy.

No need to say to always hit the enemy when you can with autos, especially with the fourth auto, but DON'T search for it unless fed!

Always remember, practice makes perfect and you'll have bad games too!