Hello I'm misterfirstblood from EUW and today I'm gonna show you how to play Vayne like gosu does.

+ Playmaker
+ True Damage
+ Duelist
+ Short cooldown dash
+ Heavy Lategame
+ You will make gosu proud when performing well

- One of the most squishy Champs in League
- Not the best early game
- Short range

Passive: Night Hunter
Vayne ruthlessly hunts evil-doers, gaining 30 Move Speed when moving toward nearby enemy champions.

Q: Tumble
Vayne tumbles, maneuvering to carefully place her next shot. Her next attack deals bonus damage.

W: Silver Bolts
Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target's max health as bonus true damage.

E: Condemn
Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, knocking them back and dealing damage. If they collide with terrain, they are impaled, dealing bonus damage and stunning them.

R: Final Hour
Readying herself for an epic confrontation, Vayne gains increased Attack Damage, Invisibility during Tumble, reduced Tumble cooldown, and more bonus Move Speed from Night Hunter

There are so many good items currently, its hard to say whats best, since a lot of build paths work.
Generally spoken: All on-hit items are great, but crit works too.
Outstandingly good items are Trinity Force Kraken Slayer Blade of the Ruined King and Guinsoo's Rageblade.
Infinity Edge and Phantom Dancer are the best ones if you decide to go for heavy crit builds with your Q.
also a honorable mention here is Statikk Shiv because this item alone solves your pushing problems.

Press the Attack works pretty well in combination with vaynes W passive.
Triumph might save your life one or the other time after going all in in a fight while Legend: Bloodline offers you needed sustain. You can also pick Legend: Alacrity to boost your damage if you feel like you won't need that sustain.
Besides that Coup de Grace is a no brainer and should always be taken on vayne as it gives you a huge damage boost.
Resolve tree offers you survivability. the staples and common choices here are Overgrowth and Conditioning

- Q resets your auto attack animation
- Using Q near to a wall resets Q animation
- Autoattack Q Auto attack E will instantly proc your W so if you see a low health opponent and cant manage to land 3 attacks in a row that might be your combo to finish them off. But pay attention, if they somehow survive it you already used E and they are probably out of range.
This Combo sees the most play under an opponents tower, since the durability patch you cant really afford to tank multiple hits when diving so this combo offers the most "Burst" damage, vayne can offer.
- You can use E and flash after to change/influence your E Target direction.
- Dont Tumble and activate ultimate after or Q is on cooldown until you attacked an enemy
- Use your ult from a brush or hidden spot and walk as far as possible before your first attack to surprise and kill enemies out of nowhere
- You can juke your enemies by activating R + Q and escape in a different direction
- Indeed vayne is a playmaker but remember your main goal is to win the game not creating a youtube montage clip and lose the game (i hope so..?)
- Dont buy Runaans on Vayne. Please :D

Vayne hasn't the best laning phase or the highest attack range and she's not easy ro master neither but if you succesful play your lane or even get a lead its a very rewarding champ.
Imo the biggest advantage you have when playing Vayne is that you dont have to take care about tanks.

Thanks for paying attention to my guide. My English is not the best so if you find mistakes feel free to correct me.

Greetings
misterfirstblood