Harm exchanges with the enemy are essential. So that in a future time of the game we can exploit the shooter of the opposing team or a threat to our shooter or support (murderers or weak bruisers)

the simplest combo the line that can make good use of the rune is:
Q + AA + W
(AA) = AutoAttack
 with this short tradeo if we do it well we will not receive damage since with the E we can leave the place quickly and avoid mass control or some kind of slowness and having made 3 consecutive attacks / skills we will activate the rune which will do extra damage at the end of the trade, always if you see the opportunity to kill the enemy instead of using the E to escape, we can use it to apply more damage to the target.

Having R we are a great threat to the ADC's if we have not been countered in the line phase we can kill them without problems.

the simplest combo with the R is:
R + E + (WQ)
(WQ) = when activating the W we can do impact damage if we use the Q with the active W for the enhanced damage, this to finish someone is something that can be very useful is in a simple way. Activate the W and use the Q on the target.