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Runes: When with enchanter support
+10% Attack Speed
+9 Adaptive (5.4 AD or 9 AP)
+6 Armor
Spells:
Exhaust
Flash
Items
Ability Order
Night Hunter (PASSIVE)
Vayne Passive Ability
Threats & Synergies
Caitlyn
Caitlyn hard outranges vayne and can easily keep her at a distance using her 90 Caliber Net (E), also Caitlyn can bully her too hard in lane to farm up and get into late game
Lulu
Lulu her kit works very will with high attack speed hypercarries, vayne being of those.
Lulu
Lulu her kit works very will with high attack speed hypercarries, vayne being of those.
Champion Build Guide
When to pick Vayne
Runes
Itemization
Combo's
End


Lethal Tempo Some people prefer to take

Berserkers In my opinion Berserkers are by far the best boots on Vayne since the attack speed makes a big difference, the boots give 35% for 1100 Gold and for instance a Rapidfire Cannon only gives 30% for 2600 Gold
Phantom Dancer I prefer Phantom dancer over any other of the zeal items since none other really gives vayne alot of use out of the unique passive.
Wits End Wits End can be a good buy in some games aswell, since it's another on hit item.
Guardian Angel Let's you play more aggressive, especially when you have a bounty on you; and gives you 40 AD and 40 armor. Nothing more to say really, same story for every champion that can build GA.
1) The most well known vayne Combo is the E + Flash to redirect the E.
2) AA + Q This makes you skip your auto attack animation
3) Using Q into a wall will cancel it's animation and will make you auto attack faster
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