Vayne and First Strike: A Deadly Combination
Introduction to Vayne and First Strike

Vayne, a highly mobile and agile AD carry in League of Legends, is known for her exceptional dueling potential and late-game scaling. She thrives in one-on-one situations, using her abilities to outmaneuver and outsmart opponents. One of the most intriguing strategies currently in the game is utilizing the First Strike rune with Vayne. First Strike is a keystone rune that grants additional gold and bonus damage to the first champion hit in combat, making it a strong choice for champions who rely on quick burst damage.

How First Strike Enhances Vayne’s Gameplay

Early Game Dominance: With First Strike, Vayne can take advantage of her high damage output right from the early levels. This rune allows her to poke and trade effectively in lane, giving her an edge over opponents who do not have the same burst potential. The extra gold from First Strike can also help Vayne reach her core items faster, accelerating her power spike.

Increased Gold Generation: The additional gold earned from First Strike helps Vayne get critical items like Blade of the Ruined King and Kraken Slayer more quickly. These items are crucial for maximizing her damage output and improving her survivability. The increased gold generation can be particularly beneficial in matchups where farming is challenging or when lane opponents are trying to zone her.

Burst Damage Potential: Vayne’s abilities synergize well with First Strike. After hitting an enemy champion, her initial attack benefits from the bonus damage from First Strike, allowing her to quickly stack her passive, W - Silver Bolts, which deals a significant percentage of the target’s maximum health as bonus true damage. This makes her capable of shredding through tankier champions and squishy targets alike.