First Sett

So everyone knows this kind of build. Back in times senna was overpowered with this one. Most players still play this build with grasp as rune. I usually go this one vs tank players or champions which are melee range and they cant really contest me. For the third item u can look for serpent if they have a lot of shield or u can mix after black cleaver and rfc, echos of heliaor even locket to be more impactfull could work with redemption tho.

Second Sett

So i go this build if is fine for me to go ionian ( look at the game statement) or if u dont need to roam. After the third item u can look for Mikaels/ Redemptions/ staff of watter depends what u prefer , even locket.

Third Sett

On this one u can adapt even with grasp or aery cleaver with a mix of items, it feels really nice echos of helia after the first cleaver item, serpent situational i guess we can go for rfc third or second with third helia

Runes

1.I usually go this type of rune when i decide is it worth for me, on the small one i choose tenacity and movement cuz i think is a good combo for the laning phase against champions like rakan/taric and something like that

2.U can adapt the grasp rune with nimbus cloak if they have a comp where u think they can focus u, its like a bait and u get out of their range i usually do this with others suport tho.

3.My favourite Page of rune. I usually prefer this one instead of grasp, boneplating is situational so it could work with inspiration tho.

4.At this moment fleet feels kinda weak maybe if it can help us to dodge something on the lane something like arcane comet or skillshots from some champs. Health regen is kinda weak.

Spells

1.Usually is good to go heal vs matchups that u think are hard to play as poke or maybe sometimes if u are good enaugh at reactions to dodge some spells or it can help u in fast trades as well.

2. Only if u think u cant handle the matchup or ur not thinking u can positioning better against that comp, also working vs assasins very well.