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LoL Best Vayne Build Guides 2025

Build guides for Vayne on MOBAFire. Find recommended items and runes by high ranked players to learn the best Vayne builds. Create your own champion guide!



Season 14 Builds
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

True Damage

Build by WARAMogs updated July 1, 2024
  • Off-Meta
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Adc Vayne Fun Build

Build by sanane74 updated June 14, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

vayne lethality

Build by bruhmomentok updated May 31, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne GUIDE

Build by Kakamari updated June 12, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne Jesuscirraptor TOP Lethality

Build by Jesuscirraptor updated May 21, 2024
  • Off-Meta
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Tank Melter

Build by WilsorBR updated May 29, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

vayne on hit build

Build by josefinosito updated May 15, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

MATH VAYNE BUILD

Build by Harmon456 updated April 17, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

SKIBIDI SIGMA VAYNE JUNGLE GUIDE OFF META

Build by serenaysarikaya updated March 25, 2024
  • Off-Meta
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne Build La build Terrorista / BUILD KESO PNDEJE

Build by MutenVer updated March 20, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne

Build by Rosewhip92 updated April 2, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne Guide

Build by NoZLXRD updated March 27, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vampire Gunners

Build by WARAMogs updated March 24, 2024
  • Off-Meta
6.4
4
Votes
2
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne top [ S14 ] (only for people with no parents)

Build by HMT_zenith updated March 15, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne

Build by GeneralHerc updated March 9, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

(Master)-Vayne off tank / Mid-Late Game

Build by mix10 updated February 7, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Hyper Carry Vayne 1 Tabs

Build by WhisperOfEternity updated February 11, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne Builds and Runes SEASON 14

Build by Tore updated January 18, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

[14.2] Vayne - Full life Steal

Build by Chironex updated January 19, 2024
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

[Season14] Vayne 1 Item Power Spike

Build by YKrow updated January 12, 2024

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