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Here's an awesome guide from KingStix explaining how to jungle as Karthus in video format.

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Welcome to Karthus' Declassified Jungle Survival Guide!

Karthus is a decent jungler right now. His kit allows you to farm well, contribute to team fights from anywhere, dominate the jungle, and give powerful ganks.

This build focuses on:

• Powerfarming
• Map control
• Changing the outcome of team fights
• Getting objectives for your team

I have a lot of experience playing Karthus jungle. I have experimented with many builds/runes and asked fellow Karthus JG mains for feedback. I've spent much time doing research, so I present to you an official Karthus JG guide!

Karthus isn't super easy, but he isn't very hard. I'd describe him as intermediate difficulty.

Karthus' camp clear is pretty good. His Q does nice damage to single-targets, while also being able to hit multiple. His E also hits multiple targets, so you can see why Karthus' wave clear is no problem. In fact, you'll want to be power-farming throughout the game. If a lane is screaming "GANK ME" because the enemy is over-extended, gank. Otherwise, farm!

Once you hit level 6, keep an eye on your mini-map. You NEED to be aware of what's going on in order to make sure your ult has impact. Ult too early: the enemies will back off. Ult too late, and your teammates are already dead. Timing is CRUCIAL! A good Karthus ult can save a teammate's life and also help take down an enemy. As long as you get an assist, its 100% worth: Don't be stingy with your ult!

As the game drags on, make sure to sometimes counter-jungle, assist in pushing lanes, save your ultimate for skirmishes/team fights, and take objectives. Karthus CAN solo dragons/herald, but a teammate's help is ALWAYS welcome AND more efficient.

Flash

You'll need this because of Karthus' low mobility.

Ignite

You're a jungler. Lol.

Domination

Dark Harvest

Some might argue Dark Harvest isn't that great. After the nerfs, it isn't what it used to be. However, Predator is pretty bad IMO, because it only works with your ult, increases channel-time, has a very long cooldown, and can't be used during Death Defied. Electrocute is viable but does not synergize with your ultimate, only with your abilities. Dark Harvest works best and infinitely scales; it is my favorite.

Cheap Shot

Works very well with your W slow and is the most viable option.

Eyeball Collection

Helps you scale even harder. Extra AP is never a bad thing!

Ravenous Hunter

Ravenous Hunter will give you some better sustain for farming camps and team fights/skirmishes. Also helps a lot when you're taking dragon/herald.

Precision

Presence of Mind

Give you better mana sustain, a MUST HAVE for Karthus because you end up using a lot of mana in fights. Also makes your ultimate cooldown shorter for every takedown.

Coup De Grace

Helps you kill enemies faster. Best option here, also gives bonus AP after a takedown; a solid rune.