Manaflow Band is very unnecessary due to you only have mana problems early and you can easily balance around this by playing smart rather than spamming abilities. Annie's main power comes from her one shot potential. that's why I pick runes like electrocute, Cheap Shot, and scorch. if you are doing even slightly better in the mid game, you can one-shot without your ult to enemy adc. Ultimate hat just for more ults to make sure i have it up at all times. The last two runes under Domination tree is more optional but I prefer Zombie Ward and Ingenious Hunter. Never use Unsealed Spellbook.
Take Arcane Comet and Gathering Storm if they had a tankier team especially in mid lane such as galio or swain or vlad. Scorch along with the other runes help you dish out enough early game damage to not have to worry too much on mana. Gathering Storm is quite worthless till later in the game so you may run into mana problems more in lane. I usually have the mindset to snowball early because Annie is best in mid game and not to wait out until late game. I see most guides recommend Arcane Comet but I would avoid this for most mid lane matchup's as you will most likely not be able to poke you enemy easily without getting poked back (unless they are melee) this is why when you go in, you want to go in full force burst hence electrocute. Even level one trade can be AA-Q-AA.

Flash-Tibbers = WRONG!. Only do this if you need the extra CC area. Otherwise W-Flash. Its a animation cancel that is instant while tibbers is a slight delay

Pre 6:
AA-Q(stun)-AA(Electrocute): Low Mana, Good Damage
Q(stun)-W-AA(Electrocute): Medium Mana, Great Damage

Post 6:
W-Flash-R--Ignite-Q-AA-Q: All in. Will 100-0 with Spellbinder if not behind
If you can't 100-0 > Q(stun)-W-AA(Electrocute)-Wait and reproc stun-W-Flash-R--Ignite-Q-AA-Q: This is generally used after first back or before first back where your combo may only do 50-70% of their health but they are still healthy enough to feel like they not need to back.
Use Spellbinder before or to help engage a fight
Use Zhonas after flashing into a team to let your team follow through

This is the same guide as One Trick Annie Guide Mid Lane but I forgot to log in so I can't edit it. Also thank you Annie Bot for help on some of the champion matchups. This is my first guide so sorry for mess up. Go to other guide for Champion v Champion notes
https://www.mobafire.com/league-of-legends/build/one-trick-annie-guide-mid-lane-525554