Hi ya, Im DevilsNightMare! Welcome to my guide!

Firstly, i want to point out that i am not a OTP on Vayne sadly. Although, i tend to play her a lot as u do have her prestige skin, icon and Vayne is also my top mastery champion

Night Hunter

EFFECT RADIUS: 2000

Passive: Vayne gains Movement speed 30 bonus movement speed when moving towards a nearby visible enemy champion.

Final Hour : Night Hunter's bonus movement speed is tripled to 90.

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Tumble

TARGET RANGE: 300

COST: 30 Mana

COOLDOWN: 4 / 3.5 / 3 / 2.5 / 2

Active: Vayne Dash dashes forward, though not through terrain, and her next basic attack within 7 seconds deals Attack damage bonus physical damage.


Bonus Physical Damage:
50 / 55 / 60 / 65 / 70% AD

Tumble resets Vayne's basic attack timer.


Final Hour Final Hour: Tumble's cooldown is reduced by 50%, and Tumble turns Vayne invisible for 1 second on-cast.

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Silver Bolts

Passive: Vayne's basic attacks and Condemn apply a Silver Bolts stack for 3.5 seconds, up to 3 times. Attacking a new enemy removes all stacks from the previous target.

The third stack consumes them all to deal Hybrid penetration bonus true damage, with a minimum threshold, and capped at 200 against monsters.


Bonus True Damage:
4 / 6.5 / 9 / 11.5 / 14% of target's maximum health

Minimum True Damage:
50 / 65 / 80 / 95 / 110

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Condemn

TARGET RANGE: 550

COST: 90 Mana

COOLDOWN: 20 / 18 / 16 / 14 / 12

Active: Vayne fires a heavy bolt at the target unit, dealing physical damage, knocking them back 475 units, and applying a Silver Bolts stack.


Physical Damage:
50 / 85 / 120 / 155 / 190 (+ 50% bonus AD)

If the target collides with a wall, they take the same physical damage again and are stunned for 1.5 seconds.

Total Physical Damage:
100 / 170 / 240 / 310 / 380 (+ 100% bonus AD)

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Final Hour

COST: 80 Mana

COOLDOWN: 100 / 85 / 70

Active: For a duration, Vayne gains bonus attack damage, triples Night Hunter Night Hunter's bonus, and grants 50% cooldown reduction along with invisibility for 1 second.


Duration:
8 / 10 / 12

Bonus AD:
20 / 30 / 40

While active, whenever a champion damaged by Vayne dies within 3 seconds, Final Hour's duration is extended by 4 seconds, up to a maximum of the original duration.

Tumble: Tumble's cooldown is reduced by 30/40/50%, and Vayne gains Invisibility for 1 second when she Tumbles.

Maximum Duration:
16 / 20 / 24

Pros

+ Destroys Late game ( Hyper carry )
+ Great in Team Fights and Split Pushing
+ One of the Best Champs that Melts Tanks
+ Huge Outplay potential
+ True Damage

Cons

- Countered by many Champions
- Very Difficult to Master
- Short Ranged
- Squishy
- Vulnerable to Crowd Control
- Banned Often
- Weak Early Game ( Needs Items to be Strong )
- Hard to Climb back up if your Behind

Key Rule - PLAY SAFE!!! Always watch what is happening! You never know whats going to happen!

Laning with Vayne can be difficult if you don't know what your doing therefore you will need to look out for OPENINGS of your opponent! Watch if you opponent is against a wall, Proc a long CD ability ( Waste ) or if they are not positioned right. That's your time to move and try to get your 3rd W stack to Proc on the enemy.

If the enemy try to push you, try to back off and let minions do damage to them as early game you do not win many trades. Vayne is a character that relies on being PATIENT and not rushing to farm cs or to out trade the opponent.

Don't forget that you have a support too. Supports also have a big impact in your lane. Always try to communicate with your support so you can engage together properly. There's a lot of strategies you can do with your supports. E.g Try to bait opponent into the open for hook, position yourself and the support to make the enemy move closer to walls, combo with their abilities etc.

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CS

Getting cs with Vayne is not too hard. Try to Use your W to last hit and secure minions. When CS'ing cannon, try to get 2 W stacks on cannon then Q and wait until the cannon is 6th of its health then basic attack. The 2 basic attack and then Q basic attack combo is great for getting CS although it should not be done often ( Try not to push Aggressively )

Under Tower CS'ing

Cannon = 7 Turret Shots + 1 Auto Attack
Melee = 2 Turret Shots + 1 Auto Attack
Caster = 1 Turret Shot + 2 Auto Attack