Best Vayne Build Guides 2025 for LoL Patch 25.08

Rating Pending

[14.2] Vayne - Full life Steal
Build by Chironex updated January 19, 2024

Rating Pending

[Season14] Vayne 1 Item Power Spike
Build by YKrow updated January 12, 2024

4.9

7
Votes
18

Master Vayne Guide 13.21
Guide by Trixiefix updated November 25, 2023

7

11
Votes
5

VAYNE TOP GUIDE 13.21
Guide by Tohru1273 updated November 3, 2023

9.5

3093
Votes
225

Season 13 - Vayne Guide - 13.20 Patch [Updated] [Ready]
Guide by Proxxii updated October 19, 2023

8.1

6
Votes
0

Season 13 ULTIMATE Vayne Guide. Every Build.
Guide by mythicdem0n updated September 4, 2023

Rating Pending

The Quintessential Vayne Guide: Walls, Rings, and Late Game
Guide by TheRealVayneGod updated September 2, 2023

8.3

120
Votes
20

Reptile - EUW Challenger #1 Vayne ADC Guide (Patch 13.16)
Guide by Reptile9LoL updated August 21, 2023

In-depth

Rating Pending

Vayne Support inspired by Woahokaybuddy
Guide by Fenreee updated August 26, 2023

Off-Meta

7.3

13
Votes
5

Vayne TOP/BOT [13.8] In-Depth Guide
Guide by ARCTIC33 updated April 29, 2023

In-depth

8.9

154
Votes
19

[13.7] BEST VAYNE TOP IN DEPTH GUIDE Detailed Match Up Sheet Included
Guide by SaskioLoL updated April 9, 2023

In-depth

7.5

12
Votes
4

Wait....Vayne has better scaling on Q than Draven?
Guide by memaybeo updated March 31, 2023

Rating Pending

vayne
Build by acredis updated December 27, 2023

Rating Pending

Vayne OffTank
Build by Bobabz updated November 8, 2023

Rating Pending

Quantum Vayne
Build by Quantum Vayne updated October 24, 2023

Rating Pending

Play Like ACE/ New School Vayne
Build by Imace updated September 1, 2023

Rating Pending

[13.14] VAYNE ONE SHOT - SPAMMING Q
Build by Bloush updated July 28, 2023

7.1

10
Votes
4

[13.11] Assassin Vayne Guide | Q Based One Shot Build
Build by Rukkivein updated June 1, 2023