Hello! I am MultiFaker (IGN: Monarch of Ice) and I play Seraphine alot, so I'm gonna share what I think are some of Seraphine's best rune setups, and (in my personal opinion) the best Seraphine build!

I believe that this is the most optimal way to play her as each item synergizes with Seraphine in a different way. Moonstone adds to your healing power which is obviously a great thing considering you do heal based on missing health. Fimbulwinter gives you free shields when you stun enemies, meaning your W heals regardless if its Echo'd or not. Rylai's is the most popular for Seraphine giving you a free root/stun since it applies slow. And other items like Vigilant and Redemption are just great utility items to help increase healing or vision.