Hey Guys !
MinceWeldSalah here to show this Champion : Darius

Hemorrhage: Darius aims his attacks strategically, causing his target to bleed. This effect stacks up to five times. Enemies that reach max Hemorrhage cause Darius to gain Noxian Might, greatly increasing his damage.

Decimate: Darius winds up and swings his axe in a wide circle. Enemies struck by the blade take more damage than those struck by the handle. Darius heals based on enemy champions hit by the blade. After a short delay, Darius swings his axe around himself, striking enemies in its path. Enemies hit by the axe's blade take 40/70/100/130/160 (+105% bonus Attack Damage) physical damage. Enemies hit by the handle take 35% damage (does not apply Hemorrhage). Darius heals for 12% of his missing Health per enemy champion hit by the blade (max: 36%).

Crippling Strike: Darius's next attack strikes an enemy's crucial artery. As they bleed out, their Movement Speed is slowed. Darius's next basic attack deals 0 physical damage and slows the target by 90% for 1 second(s).Crippling Strike refunds its Mana cost and 50% of its cooldown if it kills the target.

Apprehend: Darius hones his axe, passively causing his physical damage to ignore a percentage of his target's Armor. When activated, Darius sweeps up his enemies with his axe's hook and pulls them to him. Passive: Darius gains 10/15/20/25/30% Armor Penetration. Active: Pulls in all enemies in front of Darius and slows them by 40% for 1 second(s).

Noxian Guillotine: Darius leaps to an enemy champion and strikes a lethal blow, dealing true damage. This damage is increased for each stack of Hemorrhage on the target. If Noxian Guillotine is a killing blow, its cooldown is refreshed for a brief duration. Leaps to target enemy champion and strikes a lethal blow, dealing 100/200/300 (+75% bonus Attack Damage) true damage. For each stack of Hemorrhage on the target, Noxian Guillotine deals an additional 20% damage. Maximum Damage: If Noxian Guillotine kills the target, it may be re-cast at no cost within 20 seconds. At rank 3, Noxian Guillotine unlocks - its cooldown resets entirely on kills and it no longer has a Mana cost.

Well so many people have many different Skill Sequence on Darius
But I personally run this
I usullay start with W Crippling Strike and this helps a lot for first blood cheese method and here's an old video that shows how this method actually works .

Well now, let's talk about summoner spells to run on Darius :

is essential and it's considered the best spell for playmaking or for escaping and can combine with your E Apprehend to bring a champ who is far away from you or to complete your combo (which we willl talk about it later on) with your Q Decimate

actually works well on Darius because it let you snik to the target and apply more Passive stacks but you can get rid of it if you're counting on building Trinity Force or Black Cleaver

may be effective to get to your lane faster, participate early in the teamfight or just helps with cross-map ganking speacially on bot lane

i don't think that Darius really needs ignite because his Passive just can do the job, Besides it can help to kill secure your lane againt mostly Vladimir

BTW, please avoid taking Heal , Barrier . I also recommand not taking Exhaust but it can be efficient against Riven or Zed please AND STOP RUNNING DARIUS JUNGLE BECAUSE IT'S NOT A JUNGLER
Thanks

So in this guide I covered a lot of runes that you can run on Darius and wich all are effective and we'll start by the first Runes set which is the most popular and efficient one :
Conqueror : by far, it's the best rune to get on Darius and it's effictive to do a lot of damage and can "counter" some of the tanks like Dr. Mundo and this because of the true damage that you can get it , Rune Description : Entering combat generates one stack every second for the next 3 seconds. After reaching 4 stacks, your next basic attack against an enemy champion consumes all stacks to grants 10 - 35 (based on level) bonus Attack Damage for 3 seconds and converts 20% of your damage to champions to true damage for the duration. All stacks will wear off after 3 seconds out of combat.
Triumph : Can be effective when diving because of the amount of health that you get after killing your enemy, Rune Description : Champion Damage rating takedowns, after a 1-second delay, restore 12% of your missing health and grant an additional 20 Gold .
Legend: Alacrity : the most thing that you can get from this rune is the attack speed which helps a lot to applying Passive stacks , Rune Description : Gain 3% (+1.5% per Legend stack) bonus attack speed, up to 18% with 10 stacks.
Coup de Grace : which is basically dealing more damage to low health enemies and I really find it soo good other than the other runes , Rune Description : Deal 7% increased damage to champions below 40% maximum health.
Bone Plating : this actually gives you more resistances and reduce the amout of damage you get from your opponent , Rune Desciption : After taking damage from an enemy champion, for 1.5 seconds, the next 3 spells or attacks you receive from the SAME enemy champion deal 25 − 50 less damage.
IF YOU DON'T WANT TO USE Bone Plating , Second Wind can do the job, it helps you regenerate your health faster after taking some damage, can be really OP if combined with Doran's Shield speacially after the buff it got in the preaseaon .
Demolish : I really choose it for the extra damage for the turrets, can be very efficient if your team is behind or when you need to splitpush , Rune Description : You generate stacks on enemy structures within 600 units, up to 6 after 3 seconds. Your next attack versus a structure with 6 stacks deals 100 (+ 30% of your maximum health) bonus physical damage. Demolish will only go on cooldown upon triggering the damage.

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Sometimes you're able to run Phase Rush specially on the Full Lethality build that I create it above and we'll now discuss the Runes choice (Runes that I already mentioned previously are not taken into consideration here)
Phase Rush : Basically, it gives bonus MS after applying 3 basic attacks or abilities on a champ and so good to stink to a champion and apply the 5 stacks of your Passive , Rune Description : Basic attacks and abilities generate stacks on enemy champions hit, up to one per attack or cast. Applying 3 stacks to a target within a 3 second period grants you 25% - 40% (based on level) movement speed
Nimbus Cloak : After casting your R you gain some MS , Rune Description : Casting your ultimate ability, after a 1.5-second delay, grants ghosting and 100 bonus movement speed for 2.5 seconds. The movement speed decays over the last 1 second with 60 seconds cooldown .
Celerity : The main reason to get this, it the MOVEMENT SPEED, as you know Darius is soo good with MS that lets you stink to your enemy to get more Hemorrhage stacks, this works well also with Ghost or Youmuu's Ghostblade , Rune Description : Movement speed bonuses are 8% more effective on you (THIS DOES NOT EFFECT THE MOVEMENT SPEED YOU GET FROM BOOTS)
Scorch : and it's the most one that I like which can "burn" the enemy champ dealing MAGIC DAMAGE which is good for combining AP and AD, Rune Description : Your next ability hit sets champions on fire dealing 10 − 30 (based on level) bonus magic damage after 1 second.
Feel Free to take Waterwalking if your team is interested in fighting in Rivers or Nullifying Orb when laning vs an high AP champion or team composition . Gathering Storm also can be good when you feel that your match is going to last longer .
As you can see, Sorcery is so good to gain extra MS .

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And Finaly, the runes for the Tanky Darius which are mainly Resolve runes :
Grasp of the Undying : it deals more damage, heal you and increase the amount of max health you have , Rune Description : Dealing or receiving damage within 2 seconds generates one stack every second. At 4 stacks, your next basic attack within 6 seconds, against an enemy champion deals 4% of your maximum health bonus magic damage, restores 2% of your maximum health, and permanently grants 5 bonus health. The empowered attack duration refreshes whenever dealing or receiving damage.
Overgrowth : Thiis the only choice you can have in this tree, it just heals you from dying minions near you , Rune Description :Every 8 monsters or enemy minions that die near you permanently grants 3 bonus health.
Taste of Blood : Heal when you damage an enemy champion, Works well with your Q Decimate , Rune Description : Damaging an enemy champion heals you for 18 - 35 (based on level) (+ 20% bonus AD) (+ 10% AP).
Relentless Hunter : Gain out of combat MS after takedowns (one stack per enemy champion) , Rune Description : Gain 8 (+ 8 per Bounty Hunter stack) out-of-combat movement speed. Earn a Bounty Hunter stack for champion takedowns, up to one per unique enemy champion.

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So, I won't talk too much about the items and builds but I'll try to make things clearer and explain why I chose those runes .

Start Doran's Blade if you're really counting on going AD
And Doran's Shield for some tank The first build (see top of the page) which is AD+Tank is more common and popular because it focuses on Darius main role which is Tank and grants some AD and I highly recommend using it for all of your games . The second build which is the Full Crit one is made for "fun" , it's soo good to see your ennemies dying with one W Crippling Strike Try building full crit only if you have the lead and advantage on your enemy team with some tanky items so that you don't get one shoted . Full lethality build is another weird build but really works well specially if you combine Mobility Boots, Phage passive, Youmuu's Ghostblade and with some extra MS from your supports . And they can call you THE FAST .
You can deal a large amount of damage and you'll get some Life Steal thanks to the Blade of the Ruined King and can deal some MAGIC DAMAGE which is good for combining AP and AD, Edge of Night for some Health , Duskblade of Draktharr for removing some enemy vision and you're all done . We'll talk now about BOOTS :
Take Ninja Tabi if you're playing against mainly AD champs for bonus armor .
Take Mercury's Treads if you're playing against mainly AP champs for bonus magic resist.
Take Boots of Swiftness only if you're facing a team with a lot of crowd control that reduces slow by 25% but only in extreme cases .
Take Mobility Boots in case if you REALLY NEED the MS and when building some Full Lethality or Full Crit as I mentionned above .
AVOID TAKING Ionian Boots of Lucidity & Berserker's Greaves The most important thing with Darius is that you have to build Black Cleaver as a first item with gives you AD, Damage and CDR . Build tank on Darius if you're facing a team of Assassin or when your enemy is building Tank . Building Tank can help soo much speacially if you're loosing your lane or when you're not fed . Lastly don't forget that Spirit Visage gives you a lot +30% healing from all resources which is soooo good with your Q Decimate specially in team fights Your items build and order vary from the team you're facing, your team,and specially you so don't stick to it . Feel free to use anything you want .

In General, there are 2 known combos for Darius
But this is my personal choice

VS MELEE CHAMPIONS

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VS RANGED CHAMPIONS

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DON'T FORGET YOUR Titanic Hydra

Since Darius is a very strong champion and can punish enemy mistakes causing death, I always use this Technic (Specially when I have an advantage on the enemy) to block the enemy from Farming and gaining gold and XP
This method will let you push lanes faster and more effective at low elos because usually players at that stage are bad at farming under turret

So this is the ending of my guide, hope you enjoy it and feel free to vote for me and leave a comment .
If you notice some mistakes or issues, feel free to PM me .
As always don't forget that DUNKING is an ART
Peace,
MinceWeldSalah, EUW