It's time for the 2025 Season 1 Guide Contest! Create or update guides during the following 3 weeks to compete for the $3,750 prize pool. 🏆
LoL Best Karthus Middle Build Guides 2025
Build guides for Karthus Middle on MOBAFire. Find recommended items and runes by high ranked players to learn the best Karthus Middle builds. Create your own champion guide!
Season 3 Builds
![]()
S3 Karthus, a requiem mass for your opponent's funeral
S3 Karthus, a requiem mass for your opponent's funeral
![]()
you know what it is
![]()
S3 Zombie Karthus
![]()
Karthus' Suicide Guide! Farm and Win.
Season 2 Guides
![]()
Sustain, Steals, and Supernovas (Karthus build)
![]()
[EPIC KARTHUS GUIDE] How to rule the whole map at once
![]()
Karthus - Rape Them All [UPDATED!]
![]()
Karthus - Ok, one more song
Season 2 Builds
![]()
My "TPA Toyz"-Karthus look-up
![]()
Khartus mid- Full Archangel's Staff
![]()
The King of Death
![]()
BURST THAT ****
![]()
karthus is awsome
![]()
Karthus Die and Kill
![]()
Karthus Mid PentaKill Full AP
![]()
Karthus Build
![]()
Max Damage!
![]()
karthus
![]()
Karthus 5v5 Mid
![]()
Reaper Karthus
Create Your Champion Build Guide
Share your strategy for your favorite champion with the largest League of Legends community!
CreateYour Guide!
